PAK Research Center
Hiroshi Maruta is an expert in both molecular oncology and the major oncogenic/ageing kinase “PAK1” which is essential for a wide variety of diseases/disorders such as cancer, Alzheimer’s disease (AD), diabetes (type 2), hypertension, and a variety of infectious and inflammatory diseses (1). His team found that PAK1-deficient mutant of C. elegans lives 60% longer than the wild-type, clearing indicating that PAK1 shortens the healthy lifespan (2). Via “Click Chemitsty” his team recently developed a series of potent (highly cell-permeable) 1,2,3-triazolyl esters of COOH-bearing PAK1-blockers which are potentially useful for both cancer therapy and longevity-promotion (3-5).
molecular oncology and the major Oncogenic