Shaista Shoukat
Forman Christian College, Pakistan
Title: Various medicinal compounds can act as ligands
Biography
Biography: Shaista Shoukat
Abstract
Various medicinal compounds can act as ligands due to the presence of donor atoms such as nitrogen, oxygen and sulphur and form coordinate complexes with metal ions. As a result their structures are modified along with their medicinal properties and therapeutic effects. This is an effective way of improving their efficacy and toxicity. The present research encompasses the same concept by chelating anti-cancer drug methotrexate (MTX) with metal salts. Metal complexes of MTX were prepared with Zinc(II), Copper(II) and Chromium(III) which were characterized by elemental analysis, thermal analysis, powder XRD and other spectroscopic techniques. The spectral, thermogravimetric and elemental analysis data indicated that the synthesis of methotrexate complexes namely Zn-MTX, Cu-MTX and Cr-MTX exhibit yellow, light green and dark green colours, respectively. The proposed structures of Zn-MTX, Cu-MTX and Cr-MTX further suggested tetrahedral, square planar and octahedral geometries, respectively.