Chemistry in Drug Discovery & Designing

We know that most heterocyclic compounds are drugs or co- drugs . In our investigation furfural was used as a precursor for heterocyclic synthesis, either by ring opening of furfural going to pyrimidine derivative E3 then functionalizing this pyrimidine into its derivatives E8, E10 and cyclization into oxadiazole and thiadiazoles E8, 11. The second step involve the reaction of pyrimidine with dimedon derivatives to afford dimedono pyrimidine derivatives.The second pathway involve the synthesis of oxamyl derivative of pyrmidine E21-25 these compounds were cyclized into new oxadiazoles E24-26. The third pathway involve the synthesis of mucobromic estersE27-29 from MBA acid then these esters were converted into the correspondig lactones E30-32 and E32-36 while reacting MBA with amines affording N-alkyland N-amido lactams.The last pathwaywas the reaction MBA with methanol, sodium azide to give azido intermeddiate which was cyclized with alkene or alkynes into triazole derivatives E42-49. The synthesized compounds were characterized by IR and some 1HNMR measurments.