Drug Chemistry and Toxicology

Drug chemistry is a branch of pharmacy that overlaps with the disciplines of chemistry that involves drug design, chemical synthesis, drug formulation, drug testing, and development. Compounds used as medicines are usually organic or organometallic compounds. Today’s pharmaceutical industry evolved largely from the chemical industries. Modern advancements in biological sciences related to the structure and function of DNA as well as precise methods for manipulating DNA and making proteins has led to a more balanced partnership for drug discovery between chemistry and biology. The field of drug chemistry focuses on four key points to arrive at a compound of pharmaceutical importance, they are drug synthesis, interpretation of the chosen target to a defined pharmacodynamics and pharmacokinetics mechanism of drug action, drug screening to analyze blood, urine, hair, saliva or tissue samples to detect the presence residual chemicals and contaminants left behind in the body as a result of drug use, toxicity assessments and adverse drug reaction studies.           

The drug toxicology studies play a very important role in the drug development process that evaluates the safety of potential drug candidates. Toxicity assessments are done using relevant animal models and validated procedures. Once a new drug entity is synthesized it is subjected to various in vitro and in vivo toxicity tests. The ultimate aim of it is to translate the animal model responses into predictable toxic responses in humans. 

  • Drug synthesis and pharmaceutical formulation
  • Pharmacological interactions
  • Mechanism of drug action
  • Drug screening and toxicity assessments
  • Adverse drug reactions

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